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In vitro BBB models have revealed the role of BBB adhesion molecules, including ICAM-1, E-selectin, and PECAM-1, in transmigration of monocytes (Sguin et al., 2003), dendritic cells (Sagar et al., 2012), neutrophils (Wong et al., 2007), and lymphocytes (Wong et al., 1999)
Dont assume that animal data is the same as human data
Key Benefits
How 5-Amino-1MQ Works 5-Amino-1MQ blocks one enzyme: NNMT (nicotinamide N-methyltransferase)
Animal studies documented significant brain concentrations after oral administration, with cognitive effects comparable to subcutaneous injection
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