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focus on precursor strategies, modern clinical practice has also begun exploring direct delivery methods
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Almost no peptide permeated untreated skin over the same period
These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities
However, the therapeutic ceiling of GLP-1 monotherapy, along with the heterogeneous nature of obesity, has highlighted the significance of developing more potent agents, engaging multiple nutrient-stimulated hormone (NUSH) pathways [7]
