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These effects are mediated through entirely distinct receptor populations , MC1R on peripheral melanocytes drives melanogenesis, while MC3R/MC4R on hypothalamic PVN and limbic neurons drives pro-erectile oxytocinergic and dopaminergic signalling

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Stickel F, Kessebohm K, Weimann R, Seitz HK

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The central glycine-glycine motif provides conformational flexibility potentially important for receptor interactions