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In mice models, there was a reduction in hyperglycemia, weight loss and increased energy expenditure compared to liraglutide [68,69]
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This approach allows us to compare results of monotherapy and combination therapy in a greater picture of the clinical relevance of GLP-1RAs
In the 1960s and 70s, scientists were puzzled by the observation that oral glucose caused a much greater insulin response than intravenous glucose
This is followed by maintenance injections of 1mg every 2-3 months (or every 2 months with neurological involvement)
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