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Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin

Research focuses on its ability to upregulate the expression of vital tight-junction proteins (such as claudins, occludins, and zonula occludens-1), thereby minimizing luminal permeability while simultaneously boosting local mucus synthesis and stimulating vitamin D3 receptor expression

During kidney cancerization, expression of GSTA isoenzymes tends to decrease, which promotes the pro-oxidant environment necessary for RCC growth

Another unique feature is that the body produces glutathione inside cells, where it helps protect DNA, proteins, cell membranes, and mitochondria from oxidative damage

[Updated 2024 Dec 15]