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Incretins are largely degraded by DPP-4 in vivo, which can be hindered by substitution of first three residues or increasing steric hindrance

Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): A multicentre, randomised, open-label, parallel-group, phase 3 trial

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In type 2 diabetes management, combining a lower dose of GLP-1 therapy with other glucose-lowering medications (such as metformin or SGLT2 inhibitors) may achieve glycaemic targets whilst reducing side effects