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Examples include the GST dependent metabolism of 1,2-dibromoethane and related haloalkanes and probably also metabolism of the 6-thiopurine prodrug azathioprin [60], [5]
The differences are meaningful but subtle
Most gastrointestinal side effects, including changes in bowel frequency, are most pronounced during initial treatment or dose escalation and typically improve significantly within 4-8 weeks as your body adapts to the medication
Absolutley and it fact it is recommended
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