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Nrf2 is a transcription factor that regulates the expression of antioxidant and detoxification enzymes, such as glutathione S-transferases (GSTs), SOD, and catalase
In the 3-KO and WT groups, male mice aged 1214 weeks were divided into three subgroups including: saline control, AOD9604 administered at a dose of 250 g/kg/day, and hGH administered at a dose of 1 mg/kg/day
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The 12mg dose produces the most weight loss at 24.2% average over 48 weeks, but it also carries the highest incidence of GI side effects
Some individuals may also experience decreased appetite, suppressed food cravings, and improved mood
