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Tesamorelin has evidence for a narrow approved use, MOTS-C treatment evidence remains mostly preclinical, and retatrutide is still investigational

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J Endocrinol 170:619628 Beckman BR (2011) Perspectives on concordant and discordant relations between insulin-like growth factor 1 (IGF1) and growth in fishes

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112,113 In metastatic hormone receptorpositive breast cancer, mutations in the ligand-binding domain (LBD) of estrogen receptor 1 (ESR1), which encodes ER, contribute to treatment resistance