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Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone
Although CagriSema's 22.7% weight loss rate did not reach Novo Nordisks preset threshold of 25%, causing a near 30% drop in stock price, it was still considered to be on par with zepbond in terms of efficacy, reflecting the clinical value of amylin as a synergistic target for GLP-1, comparable to GIP
655 In addition to its role in glycolysis and ATP production, PKM2 also regulates the redirection of glycolytic intermediates to the pentose phosphate pathway, thereby generating NADPH, which is critical for cellular redox homeostasis, 656 thus shielding cancer cells from oxidative stress
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Large doses of B12 can trigger acne-like symptoms in a small percentage of people
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