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Furthermore, information on GLP-1 receptor expression in the heart is still lacking, and whether GLP-1RAs act directly or indirectly on the cardiovascular system remains inconclusive

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This figure illustrates the effects of GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors on composite cardiovascular outcomes, including all-cause mortality, progression to systolic heart failure, acute myocardial infarction, and stroke, after propensity score matching

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Lower doses (6 milligrams and 12 milligrams) also showed clinically significant weight reductions of 7.8% and 9.3%, respectively