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doi: 10.1097/MJT.0000000000000282
The medication label warns that diarrhea is a common adverse reaction
A study published in Diabetes, Obesity and Metabolism (Frias et al., 2021) from an early phase 2 comparison found that tirzepatide produced dose-dependent weight loss that exceeded semaglutide 1 mg across all dose levels tested, confirming the advantage of the dual mechanism
This difference may be due to hormonal changes, variations in hair growth cycles, or differences in nutritional status during weight loss
While some people prefill syringes for convenience, most pharmacists advise against it
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