Increased intestinal permeability is facilitated by a high-fat diet (HFD) 22 , and may allow for bacterial translocation from the gut to adipose tissue 23
In response to the muscle damage and supplementation, circulating levels of free iron (that could possibly react to form hydroxyl radicals) were increased, lactate dehydrogenase and creatine kinase, markers of protein breakdown and damage, were elevated in the supplemented group as well as an increase in markers for oxidative stress
The development of a new efficacious drug to delay, and hopefully prevent, the onset of AD symptoms must catch up with these efforts
Glucomannan is a soluble, fermentable fiber found in many plants, especially the root of the konjac plant ( Amorphophallus konjac)
Individuals who may benefit include those experiencing fatigue associated with oxidative stress or inadequate cellular recovery, people with compromised liver function or high toxic exposure, those dealing with chronic inflammation or frequent illness, athletes seeking to support faster recovery from intense training, and individuals with age-related concerns where declining glutathione synthesis is a documented phenomenon
