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Semaglutide (5mg) is a GLP1 receptor agonist
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This broad activity is the fundamental reason it produces a wider range of side effects than more targeted peptides
This effect has been noted with GLP-1 receptor agonists as a class and may be further influenced by glucagon receptor agonism
There is, however, controversy regarding expression of GLP1 receptors (GLP1R) in human normal and diseased thyroid and pancreas
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