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To determine whether zinc, rather than other ions such as copper or iron, specifically activates the ISR by inducing eIF2 phosphorylation, we assessed eIF2 phosphorylation using metal ionophores

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Metformin stimulates GLP-1 secretion from the intestine and increases plasma levels of GLP-1 both in mice and humans [31,32]

Gradual escalation reduces side effects like nausea

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