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The study found that peripheral endothelial dysfunction independently correlated with future cardiovascular events, thus providing additional clinical significance for risk stratification in HFpEF patients

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Discussion This observational cohort study describes real-world utilization patterns and characteristics of patients dispensed an SGLT2i or GLP-1 RA in the US using data from Optum CDM in the period following changes to the landscape for treatment and prevention of CKD in type 2 diabetes (later period, July 2021September 2023) as well as temporal changes in utilization and baseline characteristics relative to the period prior (earlier period, January 2012June 2021)

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While individual outcomes vary, our data shows a high satisfaction rate and lasting lifestyle improvement

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