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Over the past decades, several randomized clinical trials (RCTs) have shown that GLP-1 RAs improve cardiovascular outcomes in patients with type 2 DM (T2DM) who have established CVDs or are at risk, as well as in individuals with CKD [16,17,18,19]

6 Neurohormonal Mechanisms GLP-1RAs may modulate the activity of the autonomic nervous system by shifting the balance away from sympathetic overactivation towards parasympathetic tone

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