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Patients with a history of long-term NSAID use who have developed gastric irritation or mucosal damage that persists despite stopping the NSAIDs

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However, there are a few downsides to consider: Invasive: Receiving regular injections may be uncomfortable for some people, as it requires visiting a clinic or performing self-injections

Even in people without overt deficiency, B12 injections can correct subclinical insufficiency more rapidly than oral supplementation