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Many people choose this approach because it is cheaper and allows independent dosing

As expected

We also found that the expression levels of related genes were also upregulated

We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling