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However, this compensatory mechanism is ultimately overwhelmed

With the backing of 20 industry bodies and organisations, it is a culmination of robust discussions and broad consensus developed at the National Kidney Summit

These activated JAKs then phosphorylate STAT proteins, which then translocate to the nucleus where they regulate a set of gene transcription

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It may also be included in combination protocols for metabolic health and weight management when additional appetite control is needed alongside other therapies