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This subcluster was predominantly located in severely degenerated cartilage regions and interacted frequently with regenerative clusters (C1-2, C1-4, C2), implying that ferroptotic cells may impair cartilage repair through paracrine effects
Indirect Modulation of Energy-Sensing and Enzymatic Repair Cascades Cell therapies may indirectly influence NAD + , sirtuin, and AMP-activated protein kinase (AMPK) signaling
In addition, macrophages regulate ectopic lesion growth and angiogenesis in an autocrine and paracrine manner via extracellular vesicles (77)
Association between whole blood-derived mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease risk
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