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Avoid exposure to direct light and do not freeze, to preserve the efficacy and clarity of the solution
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If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended
This was because hydroxocobalamin produced by bacteria was changed to cyanocobalamin during purification in activated charcoal columns after separation from the bacterial cultures (because cyanide is naturally present in activated charcoal)
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