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At the same time, some patients use cannabis for nausea, which may make it harder to tell whether GLP-1 nausea is improving or simply being covered

To investigate the effects of four-week supplementation with either live or heat-killed Clostridium butyricum GKB7 (CB) on gut microbiota composition, 16S rRNA sequencing was performed on cecal microbiota samples

It's important to note that these are not established adverse drug reactions in the UK product information (SmPC) for tirzepatide, and no causal relationship has been confirmed: Low mood or depressive symptoms some individuals have reported feelings of sadness or emotional flatness Anxiety or irritability heightened nervousness or shorter temper in certain cases Fatigue and reduced motivation sporadically reported but not established as medication effects Changes in appetite and food relationships the medication's appetite-suppressing effects may alter social eating patterns and emotional connections to food These effects do not affect the majority of patients taking Mounjaro

Implications for employers: More GLP-1 type drugs are likely to become available in the coming years

Monitoring and safety Regular monitoring helps catch problems early regardless of product source