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Today, the FDA is announcing its intent to take decisive steps to restrict GLP-1 active pharmaceutical ingredients intended for use in non-FDA-approved compounded drugs that are being mass-marketed by companies including Hims & Hers and other compounding pharmacies as similar alternatives to FDA-approved drugs
Non-oral HRT (patches, gels, and injections) bypasses the stomach, so an interaction isnt expected
However, retatrutide is still being studied, and its long-term safety and tolerability are not as well known as tirzepatide
References: Madsen JM (2025): Chemical terrorism: Rapid recognition and initial medical management
Li S, He Y, Chen K, Sun J, Zhang L, He Y, et al
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