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Most gastrointestinal events were mild to moderate, occurred during dose escalation, and resolved over several weeks as tachyphylaxis developed

Do not spray it directly onto the lyophilized powder

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192 , 6571 (2010) Zhuo, X., Hartz, R.A., Bronson, J.J., Wong, H., Ahuja, V.T., Vrudhula, V.M., Leet, J.E., Huang, S., Macor, J.E., Shu, Y.Z.: Comparative biotransformation of pyrazinone-containing corticotropin-releasing factor receptor-1 antagonists: Minimizing the reactive metabolite formation