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HRD1 interacts with the Neh4 and Neh5 domains of NRF2 and causes NRF2 ubiquitination and subsequent degradation through a KEAP1-independent mechanism, just like GSK-3 [227, 228]
Other sulfur rich foods include: meat, eggs, and fish grains, including rice, bread, and pasta vegetables, such as onion, garlic, broccoli, kale, and cabbage According to a 2013 pilot study, one 250-gram portion of steamed broccoli increased the activity of the enzyme glutathione Stransferase, suggesting increased plasma levels of glutathione, and improved oxidative stress resistance in 10 healthy adult males who smoked
Rao M, Zumbro E, Dixon M, Kaiser K, Sebastian L, McAdams D, LeMieux M, Broughton KS
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