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Early assumptions that APAP toxicity is caused by a single mechanism resulting in a defined mode of cell death in hepatocytes had to be questioned when over the years many different mechanisms and modes of cell death were reported
The CD44 gene encodes a cell-surface receptor involved in various processes, including cellular differentiation, cell-to-cell adhesion, recruitment of immune system cells, and as a receptor for hyaluronic acid
PottsAUchidaADejaSBerglundEDKucejovaBDuarteJAet al
"Valproate (Belvo, Convulex, Depakote, Dyzantil, Epilim, Epilim Chrono or Chronosphere, Episenta, Epival, and Syonell): review by two specialists is required for initiating valproate but not for male patients already taking valproate"
We may speculate that a larger reduction of plasma aldosterone in the patients with advanced CKD seen in our study could be caused by a higher local activity of RAAS due to kidney dysfunction
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