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Introduction Hepatocyte growth factor (HGF) is a pleiotropic cytokine isolated as a potent cell motility factor for epithelial cells ( HGF and MET are fundamental during embryogenesis

The rationale for injectable administration stems from the limitations of topical delivery

Both selective AMYR agonists, and dual CTR and AMYR agonists such as sCT 5,6,7 , have demonstrated efficacy in controlling appetite and body weight, however this is not seen with a CTR-selective agonist 9

The hormone has far greater timeframe to circulate around the body, bind to receptors, and exert its effects

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