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As a rule, energetically favored electron promotion will be from the highest occupied molecular orbital (HOMO) to the lowest unoccupied molecular orbital (LUMO) , and the resulting species is called an excited state
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VRK2 protects PC cells from ferroptosis by facilitating SLC7A11 trafficking Since SLC7A11-mediated cystine uptake and subsequent biosynthesis of GSH detoxifies phospholipid peroxidation and protects cells from ferroptosis [26], we speculated that VRK2-deficient PC cells, vulnerable to GSH inhibition is associated with ferroptosis
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