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This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors

Glycemia reduction in type 2 Diabetes - Microvascular and cardiovascular outcomes

Tyrosine is utilized by the body in the synthesis of dopamine, adrenaline, norepinephrine, thyroid hormones, and melanin

Side effect profiles, including fatigue risk, are comparable since the medication mechanism is identical

The appeal process can take 30 to 60 days, delaying treatment and adding frustration for patients ready to start their weight-loss journey