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However, these results should be interpreted with caution due to high heterogeneity that was observed among the studies included in this meta-analysis
We found that glutathione (GSH) levels were associated with MTX resistance in both treated and untreated cells, suggesting a new constitutive metabolic-based mechanism of resistance to the drug
Numerous BACs derived from natural sources- such as curcumin, resveratrol, omega-3 polyunsaturated fatty acids, various vitamins, and polyphenolic compounds- have been extensively demonstrated to exert potent antioxidant, anti-inflammatory, and other biofunctional activities in controlled experimental settings (38)
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