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Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10

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For example, some studies have suggested that large amounts of vitamin K2 may increase bone density in people with osteoporosis

Diet-induced obese (DIO) mice (established via high-fat diet [HFD]) were subjected to 4-week interventions: cagrilintide monotherapy, semaglutide monotherapy, or cagrilintide/semaglutide combination therapy