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In a few cases, cleft lip and palate is associated with: the genes a child inherits from their parents (although most cases are a one-off) smoking in pregnancy or drinking alcohol while pregnant obesity during pregnancy a lack of folic acid during pregnancy taking certain medicines in early pregnancy, such as some anti-seizure medicines In some cases, a cleft lip or palate can occur as part of a condition that causes a wider range of birth defects, such as 22q11 deletion syndrome (sometimes called DiGeorge or velocardiofacial syndrome) and Pierre Robin sequence

The peptide has also shown preliminary interest in cartilage and joint research

Effects of glucagon-like peptide-1 on advanced glycation endproduct-induced aortic endothelial dysfunction in streptozotocin-induced diabetic rats: Possible roles of Rho kinase- and AMP kinase-mediated nuclear factor kappaB signaling pathways

Nat Cancer 7 , 260271 (2026)