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In pancreatic -cells, activation of the cAMP cascade results in enhanced glucose-stimulated insulin secretion, whereas activation of the -arrestin pathway results in GLP-1R internalization and degradation [34]
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The study employed a double-blinded design, with participants receiving a daily dose of 120mg HRS-7535 for a period of 12 weeks
The table below summarizes key differences in weight loss outcomes, mechanism, and common adverse effects across three leading GLP-1 agents
R.LivingstonL.et al
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