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However, Compound 12 was unfortunately identified as a substrate of multidrug resistance protein 1 (MDR1, P-gp) in MadinDarby canine kidney (MDCK) cells with an efflux ratio greater than 5, which precluded its development as a candidate for CNS drugs
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The findings indicate that DTNB concentrations between 2 and 5 mM provide the most accurate results for GPx
In PNA mice, that display modest metabolic dysregulation and overt gonadal perturbations, all multi-agonists decreased body weight (Fig
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