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Semaglutide is designed for subcutaneous administration once weekly and must be stored according to the manufacturers guidelines
Safe for daily use
527 Currently, the drug is in Phase II clinical recruitment to compare the safety and efficacy of three different doses in patients with nAMD (NCT05637255)
Intensive Care: Take 2-3 sticks per day starting 1-2 weeks before a specific D-day 3
This is analogous to the evidence pathway followed for liraglutide (LEADER trial, NEJM 2016) and semaglutide (SUSTAIN-6 trial, NEJM 2016), which established cardiovascular benefit for those agents only after large, long-term CVOTs reported [6] The heart rate increase warrants ongoing surveillance, particularly in patients with pre-existing cardiac conditions Phase 3 trials are currently underway (see ClinicalTrials.gov and the EU Clinical Trials Information System, CTIS, for registered studies)
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