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Additional research has focused on the relationship between NNMT activity and nicotinamide metabolism, methyl donor utilization, and cellular signaling networks associated with energy balance
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The tool followed the decision tree in Supplementary Fig
Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13
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