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Snigdha Poudyal is an inpatient clinical dietitian at MD Anderson

Studies have shown that these medications enhance insulin sensitivity and promote the breakdown of stored fat for energy

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In the case, the sisters modest weight improvement may benefit from female-specific hormonal environments (e.g., estrogen) that enhance GLP-1 receptor signaling, while the brothers limited response could be related to male-specific factors that blunt semaglutide-induced appetite suppression and energy expenditure regulation