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There is considerable interest in the potential to combine GLP-1RAs with SGLT2is because their mechanisms of action are complementary with regard to target organs, disease processes [31], and the effects seen in cardiovascular/cardiorenal outcomes trials [23,24,25,26,27,28,29, 32,33,34,35,36]

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Monitoring for Hypoglycemia As insulin resistance improves, hypoglycemia (low blood sugar) can become a concern, particularly for patients on insulin or sulfonylureas: Symptoms: Shakiness, sweating, confusion, rapid heartbeat, dizziness, hunger

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