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Some ingredients commonly found in weight loss supplements can interact with prescribed medicines for example, stimulants such as caffeine, synephrine, or yohimbine should be avoided by people taking monoamine oxidase inhibitors (MAOIs), and glucomannan may reduce the absorption of oral medicines if taken at the same time

Given the heterogeneity among GLP-1RAs in terms of pharmacokinetic profiles, therapeutic efficacy, adverse event rates, and dosing regimens, each agent should be assessed individually