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Topiramate (the chemical structure is shown in Figure 2E ) and zonisamide (the chemical structure is shown in Figure 2F ) cause metabolic acidosis before, during, and after surgery (craniotomy in patients with epilepsy) (66)
Biochemical pharmacology , 79 (7), 1000-1006
A previous real-world study on SGLT2i therapy showed a promising reduction in HbA 1c , weight and insulin requirements in type 1 diabetes but did not present long-term safety or reno-cardiovascular outcome data [25]
But tissue repair angiogenesis and tumour-feeding angiogenesis are biologically different
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