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The reason a compound like DSIP appears in a longevity-peptide curriculum at all is precisely so that clinicians can recognize a weak-evidence compound for what it is and communicate that to patients

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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation