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Phase 2 trial - Lancet, 2023 Why it matters Three pathways, not one

447 However, a controlled trial in 18 depressed women who were unresponsive to antidepressant therapy after three weeks found the addition of 5 or 10 grams creatine daily was no more effective than placebo at improving the response rate

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It is highly suitable for extended experimental protocols and dose-response studies

For most people, the practical approach involves working with a healthcare provider to establish a baseline through blood work, then adjusting session frequency based on symptom improvement and lab results