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Semaglutide carries a Boxed Warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Since the primary, if not exclusive, source of GLP-1 in the CSF are brainstem GLP-1 neurons (and not GLP-1 from the circulation 3 ), this suggests that CSF-contacting neurons are regulated by the overall activity of brainstem GLP-1 neurons

Magnesium oxide is more likely to cause digestive issues, while other forms are better tolerated

Resistance training is important for preserving muscle mass but should be introduced gradually, starting with body weight exercises or light resistance bands before progressing to heavier loads

Results remain robust across plausible ranges for most inputs