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The Drug Affinity Complex (DAC) forms a covalent bond with albumin after injection, essentially hitching a ride on a molecule too large for the kidneys to filter
M.MoroniR
4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase
These agents have both hormonal and brain targets
On the other hand, several drugs activated by GSTs require a wellfunctioning enzyme
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