87 , 11801188.e1189 (2018)
While side effects are possible, they are often manageable with appropriate screening, education, monitoring, and individualized dosage guidance
Dietary considerations may play a supportive role, although these are not proven to prevent gallstones in GLP-1 users: Maintain regular meal patterns rather than severely restricting calories, which helps stimulate regular gallbladder contraction Include moderate amounts of healthy fats in the diet (such as olive oil, nuts, and oily fish) to promote gallbladder emptying Ensure adequate hydration to support bile flow Avoid very low-calorie diets unless under specialist supervision For individuals at particularly high risksuch as those with a history of gallstones, rapid weight loss, or multiple risk factorssome specialists may consider ursodeoxycholic acid (UDCA) prophylaxis
Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism
Why it matters: Many people work long hours at desk jobs