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N Engl J Med 2001;345:851e60
When appetite vanishes, some patients eat fewer than 500 to 800 calories per day
It mimics a hormone called GLP-1, which regulates insulin and keeps food in your stomach longer
If symptoms persist after a week, move to step 2
In particular, transient interactions with residues at the base of the binding cavity correlate with enhanced kinetics for G protein activation, providing a rationale for differences in G protein-mediated signalling efficacy from distinct agonists
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