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Therefore, drugs that affect glutamine levels in the entire body are too toxic to use as cancer therapy
In the advanced PC setting, elevated plasma mGSTP1 levels have been correlated with higher Gleason score at diagnosis (Reibenwein et al, 2007)
68 Other common mutations in oncogenes such as RAS and BRAF or tumor suppressors such as TP53 did not affect the sensitivity of such tumor cells to insulin and IGF-1 in vitro or to CR in vivo
377 Deleting mutant p53 The expression of p53 mutants induces several vulnerabilities, such as specific dependencies for survival
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