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Quick Answer: GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, but some patients may experience symptomatic low blood pressure, particularly when combined with antihypertensive medications, significant weight loss, or dehydration from gastrointestinal side effects

This is dangerous because dehydration worsens almost every side effect of the drug, including nausea, fatigue, and constipation

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