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Finally, in 2023 the World Health Organization issued a guideline recommending against the use of non-sugar sweeteners for weight control or to reduce the risk of chronic disease, after a review found no long-term benefit for body fat and a possible association with type 2 diabetes and cardiovascular disease in long-term observational data

Int J Clin Pharmacol Ther Toxicol 1988;26:217-20

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